Oncology Intermediates (N-1 / N-2)

Question

Accepted Answer

Specialised in advanced N-1 / N-2 oncology intermediate chemistry — developed and supplied at commercial scale.

Product
                Therapeutic Use
                Regulatory / Grade

6,7-Dimethoxy-4-chloroquinoline
        Cabozantinib / Tivozanib
        35654-56-9

2-Amino-N-(2-chloro-6-methylphenyl)-5-thiazolecarboxamide
        Dasatinib (N-2)
        302964-24-5

N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide
        Dasatinib (N-1)
        302964-08-5

3-Aminophenylacetylene
        Erlotinib side chain
        54060-30-9

6,7-Bis-(2-methoxyethoxy)-4(3H)-quinazolinone
        Erlotinib (N-2)
        179688-29-0

R-3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
        Ibrutinib (N-1)
        1022150-12-4

3-(4-Phenoxy Phenyl)-1H-pyrazole[3,4-d]pyrimidin-4-Amine
        Ibrutinib (N-2)
        330786-24-8

Methyl-(S)-N-Ethoxycarbonyl-4-Amino phenylalaninate
        Melphalan (N-1)
        169472-17-7

4-Amino-L-phenyl-N-phthalylalanine ethyl ester
        Melphalan (N-2)
        74743-23-0

N-(2-chloropyrimidin-4-yl)-N,2,3-trimethylindazol-6-amine
        Pazopanib (N-1)
        444731-75-3

5-Amino-2-methyl-benzenesulfonamide
        Pazopanib side chain
        6973-07-9

4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoic acid
        Pemetrexed (N-2)
        137281-39-1

4-(4-Aminophenoxy)-N-methylpyridine-2-carboxamide
        Sorafenib (N-2)
        284462-37-9

Methyl-4-(4-aminophenyl)butyrate
        Chlorambucil (N-2)
        20637-09-6

Methyl-4-{4-[Bis(2-Hydroxyethyl)Amino]Phenyl}Butanoate
        Chlorambucil (N-1)
        130198-76-4

Product
                Therapeutic Use
                Regulatory / Grade

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
        Nilotinib (N-1)
        641571-11-1

6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one
        Palbociclib (N-1)
        1016636-76-2

tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
        Palbociclib (N-2)
        571188-59-5

Beta-D-Ribofuranose 1,2,3,5-tetraacetate
        Azacitidine (N-1)
        13035-61-5

5-Azacytosine
        Azacitidine (N-2)
        931-86-2

1,2,3-Triacetyl-5-deoxy-D-ribose
        Capecitabine (N-1)
        62211-93-2

4-Chloro-7H-pyrrolo[2,3-d]pyrimidine
        Ruxolitinib (N-1)
        3680-69-1

4-(4,5-Dihydro-1H-pyrazol-4-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine
        Ruxolitinib (N-2)
        941685-27-4

N-(4-cyano-3-(trifluoromethyl)phenyl)-2-methyloxirane-2-carboxamide
        Bicalutamide (N-1)
        90357-51-0

N-[3-Chloro-4-(3-fluorobenzyloxy)phenyl]-6-iodoquinazolin-4-amine
        Lapatinib (N-1)
        231278-20-9

5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester
        Bendamustine (N-1)
        3543-74-6

1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester
        Bendamustine (N-2)
        3543-73-5

2,6-Dioxopiperidine-3-ammonium chloride
        Thalidomide / Pomalidomide / Lenalidomide (N-2)
        24666-56-6

Methyl 2-bromomethyl-3-nitrobenzoate
        Lenalidomide (N-2)
        98475-07-1

4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid
        Nilotinib (N-2)
        641569-94-0